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Importantly, preclinical studies showed that weight reduction occurred particularly in abdominal adipose tissue, the visceral fat depot most strongly associated with metabolic health risks

The main effects are synthesized using a random effects model, and heterogeneity sources are explored through subgroup regression and sensitivity analysis

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Gopal Grandhige, MD, FACS, Board-Certified Surgeon Last Reviewed: March 16, 2026 BPC-157 typically begins working within the first one to two weeks, with most patients noticing subtle improvements such as reduced soreness, better digestion, and decreased inflammation during this early phase