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In Singapore, officials have sounded the alarm over vape products containing the anesthetic etomidate, which a 2024 study described as "an ultrashort-acting non-barbiturate sedative." Similarly, in the U.K., parents and public officials have expressed dismay over the rise of vape products containing synthetic cannabinoids known as "spice," which have been known to cause serious health problems and severe withdrawal symptoms
Several popular flavoring agents, including diacetyl, have been associated with serious respiratory illnesses and In one study diacetyl which can cause severe lung disease was identified in over 75% of vape liquids examined across the tobacco and cannabis sectors
