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Nationally, the e-cigarette use prevalence among high school students was 18%.2 In 2021, 2.6% of high school students in Oklahoma used chewing tobacco, snuff or dip on at least one day in the past 30 days

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Consistently, in Gpr15 +/+ mice, prolonged cigarette smoke exposure in the TNBS model led to aggravated colitis, as reflected by greater weight loss, elevated DAI, colon shortening, and worsened histological and endoscopic scores, accompanied by increased Gpr15 expression (Supplementary Fig