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Exclusion criteria Studies were excluded from this review if one of the following exclusion criteria applied: lack of access to full text, invalid results, not available in English, focused only on vaporized tobacco or tobacco-derived products, did not contain original data or data that were difficult to condense without a meta-analysis, or aims of published manuscript were not relevant to aims of this review (e.g

Total arm entries were scored as an index of total ambulatory activity

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The pouch material and contents were spiked with nicotine-D3 internal standard and extracted with 100 mM ammonium acetate solution using an ultrasonic bath