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Despite the fact that tobacco carcinogens mediate inactivation of numerous tumour suppressor genes via epigenetic mechanisms, and the fact that tobacco smoke initiates and maintains the malignant phenotype of lung cancer cells, its contribution to the prognosis of lung cancer patients remain poorly understood 8

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Rivers and lakes Dynamic tectonic movement means New Zealands landscape is dominated by mountains: more than three-quarters of our land area is higher than 200 metres above sea level

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