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Pathophysiology is likely multifactorial, with worse severity compared to IPF or COPD
Chemically identical, synthetic forms are lab-made and free from tobacco impurities or pesticides, while tobacco-derived versions come from the leaf itself
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Accordingly, it has been described that the amount of oxidative and highly reactive compounds of cigarette smoke can intensify vasodilation malfunction in a chronically inflamed microvasculature
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