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JA IQOS : exclusive IQOS use and IQOS use with combustible or smoke-free TNP) as well as frequency (past 30-day use), intensity (average daily consumption), and history (JGAP: initiation, relapse, and reinitiation with IQOS

Development of a substrate-activity based approach to identify the major human liver P-450 catalysts of cyclophosphamide and ifosfamide activation based on cDNA-expressed activities and liver microsomal P-450 profiles

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Physical dependence develops as the body adjusts to the substance, leading to withdrawal symptoms like muscle aches, irritability, and nausea