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Beyond PAHs and nicotine, other substances such as acetone, pyridine, heavy metals, benzene, and CO in tobacco smoke may also interact with hepatic enzymes, albeit their impact is considered less significant (Kroon, 2007)

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In the attempt at stopping consumption of drugs like heroin, cocaine and methamphetamine, billions of dollars have been spent on law enforcement, prisons have been filled, and the death penalty has been used the war on drugs is not just a metaphor: countries have been invaded and vast areas of land have been sprayed with plant-killing chemicals

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