GLP-1 receptor agonists slow gastric emptying and suppress appetite, which can reduce energy intake and cause fatigue Fatigue is most common during initial weeks and dose increases, often improving as the body adapts over several weeks to months Nutritional deficiencies in protein, iron, vitamin D, and B vitamins may develop when food intake drops significantly Optimising nutrition with nutrient-dense foods, maintaining hydration, and gentle physical activity can significantly reduce tiredness Contact your GP if fatigue is severe, worsening, or accompanied by signs of dehydration, hypoglycaemia, or persistent gastrointestinal symptoms Table of Contents Why GLP-1 Medications Can Cause Tiredness Glucagon-like peptide-1 (GLP-1) receptor agonists are increasingly prescribed medications for type 2 diabetes and weight management, including semaglutide (Ozempic, Wegovy) and liraglutide (Victoza, Saxenda)
Ozempic and Wegovy both contain semaglutide, yet serve distinct roles: Ozempic is for type 2 diabetes, while Wegovy is intended for chronic weight management
By focusing on these key areas, the field can move beyond correlational findings to uncover the precise causal mechanisms of T1D, paving the way for targeted interventions that can truly halt disease progression
If Thrive GLP-1 produces 5-8 pounds of weight loss, paying $250 monthly costs $30-50 per pound lost
