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Unlike oral supplements, which must pass through the digestive system before absorption, IV therapy allows nutrients to be delivered directly into circulation

Thymidine kinase-negative herpes simplex virus mutants establish latency in mouse trigeminal ganglia but do not reactivate

Practitioners also carefully screen patients: for example, they check for metal allergies (since GHK-Cu contains copper) and discuss alternative evidence-based treatments

However, mechanistic plausibility does not establish clinical benefit, and the current evidence base does not support claims of improved healing, accelerated recovery, or reduced complication rates following orthopaedic surgery