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Advances in biosynthesis, pharmacology, and pharmacokinetics of pinocembrin, a promising natural small-molecule drug

The advances reviewed herein provide a strong foundation and impetus for further exploration, ensuring that the future directions of cardiovascular therapeutics will include the wisdom of natures pharmacy, transformed by and validated through modern science

It occurs naturally in the liver and has several functions in the body, acting as a strong detoxifier and antioxidant

The formation of an NFT radical anion has been demonstrated in enzymatic assays following a one-electron reduction, e.g., by xanthine oxidase (Miller et al