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However, the greatest interest with respect to UV light carcinogenesis has been in CPDs, which are the major DNA photoproducts formed following UV light and repaired in human skin primarily by nucleotide excision repair (NER) [62, 64,65,66]

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In fact, all PDOs crystallized thus far are GSSH-catalyzing 22, 31-34 , and alignment of their structures with bound GSH product reveals features shared by these enzymes that may stabilize the GSSH substrate in the active site (Fig

Therefore, therapeutic strategies targeting intracellular regulatory environments may complement receptor-level interventions