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UV radiation exposure indirectly initiates MMP activation without upregulating collagen production, causing decreased collagen levels and ECM fragmentation (72)

SOD1 is an antioxidant enzyme that catalyzes the conversion of O into H 2 O 2 and O 2 , and is key in the regulation of OS, cell damage (Mattiazzi et al., 2002

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Therefore, the changes in the dosage form or the combination with other drugs can further compensate for the weakness of low bioavailability of berberine