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Gantt talked to her doctor, who agreed that due to her diabetes risk and inability to lose weight, she would be a good candidate for Wegovy and Ozempic, GLP-1 (glucagon-like peptide-1) drugs made by the company Novo Nordisk

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Substitution of Phe 28 * with Ala had the most severe effect on GLP-1 affinity in the Ala scan (IC 50 value increased by 1300-fold), and indeed Phe 28 * is centrally positioned in the ligand-receptor interface emphasizing the importance of this hydrophobic ligand-receptor interaction