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doi: 10.3389/fphar.2021.659584 143 WuM.YangY.WangM.ZengF.LiQ.LiuW.et al

This issue needs to be addressed more thoroughly to establish whether clinical outcomes of analgesic tolerance, as well as side effects such as respiratory depression and constipation, could be altered by directly manipulating bias toward or against agonists with different internalization capacities

The MR-Egger intercept method identified horizontal pleiotropy between serum Ca levels and GD (MR-Egger intercept = 0.010, p = 0.030), with no similar findings for other micronutrients

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