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Ciclosporin versus infliximab in patients with severe ulcerative colitis refractory to intravenous steroids: a parallel, open-label randomised controlled trial

Subcutaneous administration suffers from: Lower bioavailability Variable absorption Different pharmacokinetics Which means the systemic exposure of DSIP via subcutaneous administration is not equivalent to what is achieved with intravenous infusion

Often referred to as the "master antioxidant," it plays an essential role in protecting cells from oxidative stress and damage caused by free radicals

Until larger human trials are available, most clinicians recommend empty-stomach administration for both oral and sublingual routes