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As of January 1st, 2022, WADA officially classified BPC-157 as a prohibited substance (9)

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Physiology of peripheral and central GLP-1 signaling GLP-1 is a 30-amino acid peptide synthetized by enteroendocrine L cells of the small and large intestine, and also in the brain primarily by neurons of the nucleus tractus solitarius (NTS) within the caudal brainstem as a product of tissue-specific posttranslational cleavage of a larger precursor molecule preproglucagon (PPG)

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A safe prescribing decision also considers: eligibility and NHS pathway availability comorbidities and concurrent medicines tolerability and dose escalation patient preference and expectations capacity for follow-up and monitoring The difference between semaglutide and tirzepatide should therefore be framed as a clinical comparison, not a direct consumer recommendation

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