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Highly reactive species such as hydroxyl radical (OH) and perhydroxyl radical (HO 2 ) emerge from secondary interactions involving O 2 - NAFLD progression is further driven by insulin resistance (IR), ER stress, and the activation of the unfolded protein response (UPR) pathway [52, 53]

If TSH is mildly elevated The evidence to support levothyroxine therapy in patients with subclinical hypothyroidism with TSH levels less than 10 mIU/L remains inconclusive, and the decision to treat should be based on clinical judgment.2 The studies that have looked at the benefit of treating subclinical hypothyroidism in terms of cardiac, neuromuscular, cognitive, and neuropsychiatric outcomes have included patients with a wide range of TSH levels, and some of these studies were not stratified on the basis of degree of TSH elevation

The body naturally produces the hormone GLP-1 (glucagon-like peptide-1) to control blood glucose levels and promote insulin secretion