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Dysfunctional BMPR2 signaling drives an abnormal endothelial requirement for glutamine in pulmonary arterial hypertension

One second study evaluated exenatide and oxycodone in mice and reported that the systemic injection of exenatide into the NAcc shell reduced oxycodone self-administration and responses in a reinstatement paradigm.164 However, consistent with prior findings, exenatide did not significantly influence the analgesic effects of oxycodone, as assessed by the tail-immersion test.164 Recently, the Icelandic drug monitoring system reported cases of suicidal ideation and self-harm among patients treated with GLP-1RAs, prompting a review by the European Medicines Agency.165 Currently, there is no evidence indicating that GLP-1RAs increase suicidal behavior

This creates a regional pattern that does not resemble the results obtained with any other serotonergic drug using this method. Why This Matters This nigrostriatal focus is mechanistically intriguing because these regions are heavily involved in motor control, reward processing, and motivation

** Daily values could not be determined