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Metsera took a slightly different approach, but like everyone else in the GLP-1 space found out that actually slow titration is better

When the medications reach the brain and bind to receptors in the habenula, they reduce the compulsive pull behind behaviors like overeating often described by patients as food noise. Thats one reason why GLP-1s are now being studied as potential tools for treating or preventing substance use disorders

The list exists because they do happen occasionally, and the combination of two metabolically active drugs makes some symptoms harder to attribute to one cause

N- methylation, on the other hand, adds a small methyl group to the nitrogen of the peptide bond