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Hemin-induced platelet activation and ferroptosis is mediated through ROS-driven proteasomal activity and inflammasome activation: protection by melatonin

The assay is based on the conversion of citrate to isocitrate, to -ketoglutarate, which results in the production of NADPH

Additionally, recent studies have found that the expression of GPX4 and GSH was disordered in rats administered DOX [92]

While members of this family carry an autosomal dominant APP duplication rearrangement that leads to early-onset familial AD, including pre-symptomatic (do not fulfill yet the diagnostic criteria) and symptomatic (with clinically diagnosed AD) patients, subjects from the same family in which the genetic testing did not show the APP duplication were considered as non-carrier healthy controls