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Emerging evidence suggests that natural products derived from medicinal plants, dietary components, animals, and microorganisms may modulate PCD in granulosa cells through various molecular mechanisms and signaling pathways

As individuals grow older, the body's ability to synthesize and maintain optimal glutathione levels diminishes, contributing to a gradual decrease in its availability

Key antibodies used included: anti-FOXO4 (two different clones, ab128908 and sc-373877), anti-StAR, anti-CYP11A1, anti-3-HSD, and anti-Ser15-phospho-p53

Encouragingly, efforts are underway to improve reporting and reproducibility