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Pit-1 is mainly expressed in the pituitary somatotrophs, but it has also notably been demonstrated to be expressed in extrapituitary tissues

How IGF1 LR3 Works: Stimulates muscle cell proliferation and differentiation Activates satellite cells , leading to muscle repair and growth Increases glucose and amino acid uptake into muscle tissue Enhances protein synthesis and reduces muscle breakdown (catabolism) Promotes neuroregeneration and cellular recovery IGF1 mediates many of the growth-promoting effects of growth hormone and has potent anabolic effects on skeletal muscle. Florini et al., Annual Review of Physiology IGF1 is naturally stimulated by growth hormone via the liver

(1997) Synergism Between GHRP-6 and GHRH in Stimulating GH Secretion in Rats J Neuroendocrinol 9(9):671677

This mechanism was also confirmed in subsequent studies