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In addition, metabolomics analysis allows us to identify galactitol and galactonate, two metabolites produced by hepatic galactose metabolism, whose serum and urine postprandial levels increase in LP, but not in LNP, subjects who ingested lactose, being proposed as novel and non-invasive lactose digestion test for LI screening [140]

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the OCR/ECAR ratio serves as an indicator of metabolic preference and can help guide rational combination strategies