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To overcome the above-mentioned hurdles of intranasal drug delivery, peptides and proteins can be modified to increase their membrane permeability and stability, by supplementing the drug with enzyme inhibitors that perturb the pseudo-first-pass effects (Pires et al., 2009)

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Sold as Vyleesi, bremelanotide was approved in 2019 for premenopausal women with acquired, generalised HSDD clinically defined as low sexual desire causing significant personal distress