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Compared to popular GLP-1RAs like semaglutide, orforglipron does not require injection or an absorption enhancer with fasting to achieve exposure, and it can be taken without water or food restrictions, according to Phase 1 pharmacokinetic data

In addition, deletions in the 15q13.3 region that contains the CHRNA7 gene, which encodes the 7nAChR, are linked to a range of neurodevelopmental problems, including ASD [162, 163]