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Skillbck et al., 2017) indicate the vulnerability of the NVU in Alzheimers disease, the most common neurodegenerative disease (Muoio et al., 2014), and both protective and trophic functions of the neural barrier seem to be impaired (Zenaro et al., 2017)

The addition of exogenous melatonin improves the intestinal microbial composition and circadian rhythm in high-fat diet-fed mice, thereby regulating the hosts metabolic circadian clock and lipid metabolism [57]

In many bacteria, the reactions of the -oxidation cycle can be carried out by multiple proteins (FadA to FadM), with FadE as the acyl-CoA dehydrogenase, FadB as the dual enoyl-CoA hydratase and 3-hydroxylacyl-CoA dehydrogenase, and FadA as the 3-ketoacyl-CoA thiolase (see Fig 1