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The levels of 4-HNE are remarkably elevated under conditions of oxidative stress and it is considered as one of the reliable biomarker of oxidative stress 64

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We could even observe change in erythrocyte debris from a group of colourless debris with a few dark brown SHGs to a group with increasing number of dark brown SHGs, which marked the gradual process of utilization of erythrocyte debris to form more new SHGs (Supplementary Fig

239,241 RAGE antagonists are being explored to block the downstream effects of AGE-RAGE interactions to reduce inflammation and oxidative stress in DPN