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Alexander EK, Pearce EN, Brent GA, Brown RS, Chen H, Dosiou C et al (2017) 2017 Guidelines of the American Thyroid Association for the Diagnosis and Management of Thyroid Disease During Pregnancy and the Postpartum

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This structural modification reduces binding to IGF-binding proteins (IGFBPs), and preclinical evidence indicates that this truncated analog is more potent than native IGF-1 in bioassay models

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