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There are two distinct types of neurons in ARC that are important in control of food intake

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The FDA first approved sermorelin (brand name Geref) in 1990 as a diagnostic agent to evaluate pituitary gland function

This lack of benefit stands in contrast with the significant or nearly-significant reduction in macrovascular risk reported with liraglutide, semaglutide and exenatide [51,52,53], which also enhance signaling through the GLP-1 receptor [54]