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Pharmacologic treatment options for obesity: what is old is new again

Feeling cold is not listed as a recognised adverse effect in the Summary of Product Characteristics (SmPC) approved by the Medicines and Healthcare products Regulatory Agency (MHRA), though some patients report increased cold sensitivity whilst taking this medication

doi: 10.1111/are.14322 [DOI] [Google Scholar] [11].Nantongo M, Mkupasi E, Byarugaba D, et al

Key Takeaways: PRP as a First-Line Injection for Knee Osteoarthritis Stronger and longer-lasting pain relief than HA and corticosteroid injections Reduces inflammation and promotes cartilage repair , rather than just masking symptoms Potential to slow OA progression , making it a disease-modifying therapy Fewer side effects compared to corticosteroids, which can accelerate cartilage loss with repeated use Given the growing body of high-level clinical evidence , PRP is increasingly being recommended as a first-line regenerative therapy for knee osteoarthritis, offering a biological approach to symptom management and disease modification