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To evaluate the incidence of MACE-4 events in patients treated with tirzepatide compared to the control group, a meta-analysis was conducted using data from 7778 patients enrolled in the SURPASS-4 study, SURPASS Clinical Trails Program (which includes 7 randomized clinical trials), and SURMOUNT-1

Exenatide was found to lower the levels of high sensitivity-C-reactive protein and endothelin-1 in comparison to glargine insulin in another study [63]

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While clinical evidence remains limited, both peptides may have potential applications in supporting chondrocyte viability and potentially attenuating cartilage degradation processes associated with osteoarthritic conditions