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Participants who were male, over the age of 55, Black, did not provide income data, and did not experience headaches, depression, anxiety, or have cancer, scored significantly higher on PROMIS

Hormone replacement therapy involves tailored treatments to restore testosterone or estrogen levels, improving energy, mood, and metabolic function

Declines in mitochondrial function i.e., decreases in mitochondrial DNA volume and integrity are linked to accelerated aging

Hence, in addition to common pro-inflammatory mediators like IL-6, TNF- and IL-1, reducing NLRP3 inflammasome activity can alleviate obesity-associated metabolic abnormalities