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In cases of unexplained macrocytic anemia associated with high homocysteine levels and normal B 12 testing results, folate testing may be arranged if supported by laboratory specialist consultation

The signaling pathways of nuclear factor kappa B (NF-B), mitogen-activated protein kinase (MAPK), and signal transducer and activator of transcription 3 (STAT3) are among the major targets that can be influenced by ROS