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Side Effects and Risks For a healthy adult getting a routine drip from properly trained staff, IV therapy is usually well tolerated

While genetics does not predict exact tapering response, certain variants correlate with stronger hunger signals post-discontinuation, informing more cautious protocols

Other groups have reported increased efficacy with 5FU and metformin in models of acquired resistance 53,54,55,56 , in spheroid culture 53 or xenograft/PDX models 57,58,59 , but the potential of combined 5FUCI inhibitor co-treatment in a chemo-naive, immune-competent setting requires further investigation