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After pooling the fractions containing pure 3,4- cis -leucocyanidin ( 6 ), MOPSO was added to a final concentration of 10 mM, the pH was set to 6.2 using 5 N NaOH and the pooled fractions were rotary-evaporated to a concentration of 7 mM of 3,4- cis -leucocyanidin ( 6 ), quantified by HPLC-UV (280 nm) with an external calibration curve with 3,4- trans -leucocyanidin ( 14 )

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This synergy aims to minimize drug toxicity while augmenting therapeutic efficacy in the treatment of cancer ( Natural phytochemicals found in herbs, cereals, seeds, and other plants offer a potential alternative, as they possess bioactive compounds with protective or disease-preventing properties ( Statements Author contributions CX and YC conceptualized the manuscript

doi: 10.1111/j.1365-2567.2011.03506.x [DOI] [PMC free article] [PubMed] [Google Scholar] 43