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Other conditions that cause macrocytic anemia include: Hypothyroidism (underactive thyroid) Liver diseases Excess production of red blood cells by the bone marrow following blood loss or to correct anemia Medications, such as: Cancer drugs Antibiotics, trimethoprim-sulfamethoxazole Immunosuppressants, methotrexate Antiretroviral drugs for human immunodeficiency virus 5-fluorouracil, zidovudine Anti-seizure drugs Gastric bypass is done to manage cancer or for weight loss purpose Parasitic infections, such as tapeworm A minor degree of macrocytosis (mean corpuscular volume rarely greater than 110 fL) may be noticed after: Recent hemorrhage (more than one week) Hemolytic anemia (anemia caused by rapid death of RBCs) 16 symptoms of macrocytic anemia The patient may have general symptoms that are typical for anemia, which range from mild to severe and includes: Fatigue Diarrhea Pallor Dizziness Breathing issues Rapid heartbeat Poor concentration Loss of balance Loss of appetite Weight loss Numbness and tingling in the arms and legs Confusion Memory loss Depression Mouth ulcers Hair loss It is recommended to consult the doctor if a person experiences any serious symptoms, especially increased heart rate, breathing problems, and neurological issues
Balenovic D, Bencic ML, Udovicic M, Simonji K, Hanzevacki JS, Barisic I, et al
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