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Serious digestive issues like severe stomach pain, pancreatitis, or gallbladder problems have been reported

Diagnosis and Testing: What to Review Before Starting or Switching When discussing semaglutide or tirzepatide with your clinician, they'll ask about your weight history, check your blood pressure, and go over your current medications and supplements

Side effects are generally manageable with proper dietary adjustments and hydration

For anyone on regular long-term painkillers, a periodic review with your GP is worth scheduling, both to assess whether the medication is still needed and to check for side effects