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While SS is characterised by neuromuscular hyperactivity (hyperreflexia with clonus, myoclonus, and tremor), in NMS, there is usually decreased neuromuscular activity with extrapyramidal features (hypokinesia and lead-pipe rigidity)

The elevated expression of 20S proteasome (increased PSMA6), which play an important role in the elimination of oxidized proteins, might be one of the mechanisms that account for reduced levels of oxidized proteins in male livers

Dosage-dependent phenotypes in models of 16p11.2 lesions found in autism

However, reduced dietary intake due to appetite suppression may decrease B12 consumption, particularly in patients with additional risk factors such as restricted diets or concurrent medications affecting absorption