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This allowed us to isolate the effect of prolonged stress on fear extinction, demonstrating that PTSD-model mice (fear conditioning + SPS) exhibited impaired extinction retrieval compared to the footshock-only group, despite acquiring similar levels of fear during conditioning
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Finally, lactylation-driven immune suppression within the TME reduces the efficacy of immunotherapies, such as immune checkpoint inhibitors (ICIs), by dampening anti-tumor immune responses [38]
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