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doi:10.1016/j.ejim.2021.01.002 Sumithran P, Prendergast LA, Delbridge E, et al

they usually occur earlier in life

GLP-1 medications in particular are sensitive to disruption

[55] It does this by upregulating phosphorylated IRS-1 and activating pathways (like AMPK/SIRT1) that promote the transport of the GLUT4 glucose transporter to cell membranes in muscle and adipose tissue, thereby increasing overall cellular glucose uptake