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This work has culminated in the synthesis of a small molecule AT 4 receptor agonist capable of penetrating the blood-brain barrier and facilitating cognitive processing presumably by increasing synaptogenesis (133)
Previous research has indicated that projections from the ventral tegmental area (VTA) to the BLA are implicated in the regulation of anxiety-like behaviors [11], and that inflammation within the BLA can intensify anxiety and depressive behaviors in mice [12]
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Oral non-steroidal anti-inflammatory drugs (NSAIDs) such as ibuprofen may be considered for short-term use, but discuss with your GP or pharmacist first, particularly if you have diabetes-related kidney concerns, heart disease, or gastrointestinal risks
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