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GLP-1 nanomedicine alleviates histologic changes observed in DSS induced colitis Histologic analyses of distal colonic tissues showed that mucosal structures were significantly damaged in DSS treated mice, as manifested by damage to crypt structures and high levels of neutrophil infiltration (Figure 2, B )

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To further confirm that MT exerts its effects through MT2, H1703 cells were treated with MEL-1A-R siRNA or MEL-1B-R siRNA to generate MT1 and MT2 knockdown cell lines

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