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Phytochemicals provide protection during sensitive developmental periods, allowing the plant to reach maturation and continue to propagate ( In mammals, sulforaphane can similarly upregulate stress-induced signaling pathways, including the Nuclear Factor Erythroid 2-related Factor 2 (NRF2) transcriptional pathway, which is conserved across mammalian species, but absent from plants ( 2 Discovery of sulforaphane and the NRF2-ARE pathway Sulforaphane is an isothiocyanate, derived from the precursor glucoraphanin (Matusheski et al., 2004