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3 In general, this GLP-1 agonist has been shown to have effects on -cell proliferation and neognesis, inhibition of apoptosis (programmed cell death), cellular stress reduction, and insulin transcription, synthesis, and secretion

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Superior Weight Loss Efficacy Study from 2020 concluded that semaglutide provides superior weight loss efficacy with no demonstrable link to gastrointestinal adverse events. These adverse events include stomachaches and diarrhea

Currently, a large trial is ongoing assessing the long-term effects of semaglutide on DRP in patients with T2D as primary outcome (FOCUS trial, NCT03811561)