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This work demonstrates the potential clinical utility of Dihexa as a co-administered protectant to prevent aminoglycoside ototoxicity

3.5 GHK-Cu regulated the SIRT1/STAT3 pathway SIRT1, which is closely associated with cellular metabolism and stress responses, also interacts with the STAT3 pathway (Figures 6AD, DSS-induced mice exhibited significantly increased SIRT1 expression and decreased p-STAT3 expression compared to the Control group

The temporal dynamics of 5-amino-1MQ's cellular effects reveal sophisticated regulatory mechanisms that extend well beyond immediate enzyme inhibition

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