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This addiction primarily stems from the presence of nicotine, a potent psychoactive substance found in tobacco, according to an article by the Center of Addiction and Mental Health titled Nicotine Dependence. The addictive nature of tobacco leads individuals to develop a tolerance, necessitating higher amounts to achieve the same effects, ultimately reinforcing the cycle of dependence

doi: 10.3389/FROH.2021.642238 50 Nolan-KenneyR.WuF.HuJ.YangL.KellyD.LiH.et al