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FIGURE 5 Exendin-4 Preserved Blood-Brain Barrier Integrity Through Glucagon-Like Peptide 1 Receptor/Activated Protein Kinase/Nuclear Factor-Kappa B Pathway To investigate the potential mechanisms of Ex-4 in BBB protection, Western blot was performed on the downstream proteins of GLP-1R at 24 h after SAH (representative images in Figure 5B)

In September 2023, the FDA asked Novo Nordisk to add the gastroparesis risk to its label