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Some, liver-to-blood clearance of plastic was seen, but most of the particles were excreted through the urine, while high levels of particles remained and accumulated in the liver, spleen and gallbladder

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Conversely, KLOWs specificity is a limitation if the research goal is systemic rejuvenation

Transcriptional profiling studies further reveal that astrocyte subpopulations adopt divergent states ranging from neuroprotective to neurotoxic phenotypes in neurodegeneration, further underscoring the importance of astrocytic heterogeneity 40,41