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Patients with diabetes who are initiating GLP-1 RAsespecially those with elevated baseline hemoglobin A1c or anticipated rapid reductionmay benefit from being monitored more closely than suggested by the American Academy of Ophthalmology preferred practice pattern, which is based on the current level of retinopathy

Such drastic differences in microbiota compositions across geography highlight the challenges in using gut microbiota compositions as a sole diagnostic biomarker

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